Gastroparesis
Pathologically delayed stomach emptying — rare, headline-grabbing, and distinct from the routine GLP-1 slowing effect.
Gastroparesis is a diagnosis: the stomach emptying so slowly that food lingers abnormally, causing persistent vomiting, early fullness, and nutritional trouble — most often from diabetic nerve damage. GLP-1 drugs slow emptying by design, and lawsuits plus headlines have blurred the line between that intended effect and the disease.
The honest state of evidence: intended slowing is universal and reverses when the drug stops; severe persistent cases are rare, and pre-existing gastroparesis is a reason to avoid these drugs. The symptom boundary is persistence — vomiting undigested food many hours after meals, ongoing inability to finish small portions, weight falling faster than intended — which warrants evaluation rather than another escalation step.
This glossary entry is general information, not medical advice, and is written to be consistent with FDA prescribing information and primary trial publications as of its last review. Always consult a licensed healthcare provider for personal medical decisions.
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